Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 1;12(4):336. doi: 10.1038/s41419-021-03642-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a RANK mRNA levels in CRC tissues and normal colorectal tissues were detected by analyzing the dataset GEPIA. *P < 0.05. b Representative images of different grades of RANK staining intensity were shown in CRC tissues. Staining results were classified as − (score 0), + (score 1–4), ++ (score 4–8), and +++ (score 9–12). IgG was the negative control for staining. NC negative control. c Representative RANK IHC staining in CRC tissues (stage I, stage II, stage III, and stage IV) and matched normal tissues far away (>10 cm) from the malignant lesion. d Characterization of RANK expression in CRC tissues and closely adjacent para-carcinoma tissues in eight patients (P1–P8). e Distribution of RANK expression in CRC tissues and matched normal tissues (P < 0.0001). f Percentage of RANK expression in CRC tumors within individual TNM stage (P < 0.0001). g Kaplan–Meier analysis of overall survival in CRC patients. h Kaplan–Meier analysis of disease-free survival in CRC patients. i Western blotting of RANK protein expressions in eight paired tumor and normal tissue samples. The tumor/normal ratios of RANK were quantified using the ImageJ software. Expression levels were normalized with GAPDH. T human CRC tissues, N paired normal colorectal tissues. Scales bars = 200 μm (100×), 100 μm (200×), and 50 μm (400×).