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. 2021 Apr 1;12(4):336. doi: 10.1038/s41419-021-03642-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b Cyclosporin A (CsA) gradually attenuated RANK-induced migration and invasion in SW480 and Caco2 cells at 1, 5, and 10 μg/ml. Scales bars = 100 μm. c A total of 10 μg/ml CsA significantly decreased the nuclear translocation of NFATC1 in SW480RK and Caco2RK cells analyzed by western blotting. d Western blotting showed that 10 μg/ml CsA reversed the ACP5 levels in RANK-overexpressing CRC cells. Data are mean ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.