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. 2021 Apr 1;12(4):336. doi: 10.1038/s41419-021-03642-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Western blotting analyzed the protein levels of NFATC1 and phosphorylated NFATC1 in nuclear and cytoplasm of 100 μM 2APB-treating CRC cells. b Immunofluorescence staining showed nucleocytoplasmic localization of NFATC1 in CRC cells treated by 100 μM 2APB. Blue represents DAPI staining. Scales bars = 20 μm. c, d A total of 100 μM 2APB rescued RANK-mediated migration and invasion of SW480 and Caco2 cells. Scales bars = 100 μm. e–g Scatter plots showed the significant positive relationship between mRNA expressions of IP3R and PLCγ obtained by online datasets. PLCG1, PLCγ. ITPR3, IP3R. h A total of 10 μM U73122 rescued the protein levels of STIM1, ACP5, and the phosphorylation level of NFATC1 in SW480RK and Caco2RK cells. i, j Representative images of CRC cells treated by 10 μM U73122 subjected to the transwell migration and invasion assays. Scales bars = 100 μm. Data are mean ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.