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. 2021 Apr 1;7:7. doi: 10.1038/s41514-021-00060-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a IF micrographs of H2A.J staining in human epidermis of young (<30 y), middle-aged (30–60 y), and aged (>60 y) donors. b Graphic presentation of H2A.J expression (H2A.J+ cells in percentages) depicted for the entire age cohort (n = 53; left panel) and depicted per age-group (right panel: the horizontal line in the box represents the median, the box shows the interquartile range [25th–75th percentile] and the whiskers represent the 5th–95th percentile.) c Graphic presentation of H2A.J expression (H2A.J+ cells in percentages) in different epidermal layers in relation to donor age. ***p < 0.001 significant statistical difference to younger age-group.