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. 2021 Apr 1;7:7. doi: 10.1038/s41514-021-00060-z

Fig. 2. Proliferative capacity, DNA-damage foci, and H2A.J during human skin aging.

Fig. 2

a IF micrographs of H2A.J and Ki67 double-staining in young, aged, and irradiated skin (upper panel). Graphic presentation of the quantification of H2A.J+ and Ki67+ cells in epidermis of young (<30 y), middle-aged (30–60 y), and aged (>60 y) donors (n = 3 per age-group). b IF micrographs of 53BP1 and H2A.J double-staining in young, aged and irradiated skin. Graphic presentation of the quantification of 53BP1+, H2A.J+, and double-positive cells in epidermis of young (<30 y), middle-aged (30–60 y), and aged (>60 y) donors (n = 3 per age-group). Data are presented as mean±SE; **p < 0.01, ***p < 0.001 significant statistical difference to younger age-group. Red, broken lines in the bar graph indicate the results for irradiated skin.