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. 2021 Apr 1;7:7. doi: 10.1038/s41514-021-00060-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a IF micrographs of telomere (hybridized with telomere-specific PNA probe, red) and centromere 2 (green) FISH staining in human blood lymphocytes (left panel). Graphic presentation of relative telomere-length measurements in blood lymphocytes of donors of varying age (n = 51) are given as fluorescence ratio units (FRU). Solid trend line indicates age-dependent relative telomere-length reduction up to 60 years. b IF micrographs of telomere (red) and centromere 2 (green) staining in human epidermal keratinocytes (left panel) of tissue sections. Graphic presentation of the mean relative telomere length as arbitrary fluorescence units per nucleus (AFU) in epidermal keratinocytes of donors of varying age (n = 51). Solid trend line indicates an age-dependent telomere-length reduction up to 50 years.