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. 2021 Apr 1;7:7. doi: 10.1038/s41514-021-00060-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Micrographs of telomere FISH signals (green) and 53BP1 IF signals (red) in human epidermal keratinocytes of young (<30 y), middle-aged (30–60 y) and aged (>60 y) skin. Selected areas are shown below at higher magnification. b Graphic presentation of epidermal keratinocytes quantification with telomeric 53BP1-foci in human skin of donors of varying age (left panel, n = 53). Graphic presentation of epidermal keratinocytes quantification with H2A.J expression, 53BP1-foci, and telomeric 53BP1-foci in the stratum basale of donors of varying age. Data are presented as mean±SE; **p < 0.01, ***p < 0.001 significant statistical difference to younger age-group.