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. 2021 Apr 1;7:7. doi: 10.1038/s41514-021-00060-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a IF micrographs of integrin-α6 expression in young and aged human skin. The selected area is shown at higher magnification (left panel). Quantification of integrin-α6+ cells in human epidermis of donors of varying age depicted per age-group (upper panel: The horizontal line in the box represents the median, the box shows the interquartile range [25–75th percentile] and the whiskers represent the 5–95th percentile) and for the entire age cohort (n = 52; lower panel). ***p < 0.001 significant statistical difference to younger age-group. b Micrographs of H&E stained human skin of young and aged donors. Measured areas of the epidermis (without corneal layer) are indicated by black lines. Graphic presentation of measured epidermal areas and integrin-α6+ cells in relation to donor-age (n = 52).