Table 1.
Summary of GWS associations for SNPs identified as contributing to both ADHD and MDD.
| SNP | Position | Ref | Alt | OR (ADHD) | P (ADHD) | OR (MDD) | P (MDD) | OR (combined) | P (combined) | LD range | Protein coding genes overlapping LD range |
|---|---|---|---|---|---|---|---|---|---|---|---|
| rs12658032 | chr5:103904226 | A | G | 1.07 (1.05–1.10) | 1.2e−07 | 1.05 (1.03–1.07) | 1.2e−10 | 1.06 (1.04–1.07) | 1.5e−16 | chr5:103671867..104082179 | |
| rs4593766 | chr1:73773043 | T | C | 1.05 (1.02–1.08) | 6.4e−05 | 1.04 (1.03–1.06) | 1.7e−08 | 1.04 (1.03–1.06) | 4.9e−12 | chr1:73666614..73991792 | |
| rs61867322 | chr10:106647839 | A | G | 0.93 (0.90–0.96) | 7.2e−06 | 0.95 (0.94–0.97) | 5.3e−06 | 0.95 (0.93–0.96) | 6.4e−10 | chr10:106529451..106797515 | SORCS3 |
| rs2509805 | chr11:57650796 | T | C | 1.05 (1.02–1.08) | 2.7e−04 | 1.04 (1.02–1.06) | 5.3e−07 | 1.04 (1.03–1.06) | 6.4e−10 | chr11:57641883..57661032 | |
| rs113901452 | chr5:44816452 | A | G | 1.10 (1.05–1.16) | 1.4e−04 | 1.08 (1.04–1.11) | 1.0e−06 | 1.08 (1.06–1.11) | 8.1e−10 | chr5:44816452..44861664 | MRPS30 |
| rs1371048 | chr2:145753166 | T | G | 0.94 (0.91–0.97) | 4.8e−05 | 0.96 (0.94–0.97) | 6.1e−06 | 0.95 (0.94–0.97) | 2.3e−09 | chr2:145701992..145753166 | |
| rs8084351 | chr18:50726559 | A | G | 1.04 (1.02–1.07) | 4.1e−04 | 1.03 (1.02–1.05) | 1.2e−06 | 1.04 (1.02–1.05) | 2.4e−09 | chr18:50716945..50737950 | DCC |
| rs139161896 | chr12:89802804 | A | G | 1.15 (1.08–1.22) | 8.8e−05 | 1.10 (1.06–1.14) | 5.1e−06 | 1.11 (1.08–1.15) | 3.2e−09 | chr12:89721105..89904596 | DUSP6 POC1B |
| rs2029591 | chr3:49646981 | T | C | 1.07 (1.04–1.11) | 1.7e−05 | 1.04 (1.02–1.06) | 2.8e−05 | 1.05 (1.03–1.07) | 5.9e−09 | chr3:49193081..49890967 | AMIGO3 AMT APEH BSN C3orf62 C3orf84 CAMKV CCDC36 CCDC71 CDHR4 DAG1 FAM212A GMPPB GPX1 IP6K1 KLHDC8B MST1 NICN1 RHOA RNF123 RP11-3B7.1 TCTA TRAIP UBA7 USP4 |
| rs2433018 | chr15:47677596 | A | G | 0.94 (0.91–0.97) | 3.5e−05 | 0.96 (0.94–0.98) | 2.8e−05 | 0.95 (0.94–0.97) | 1.1e−08 | chr15:47659445..47685378 | SEMA6D |
| rs12226775 | chr11:49179289 | T | C | 1.10 (1.05–1.14) | 1.8e−05 | 1.05 (1.02–1.08) | 6.4e−05 | 1.06 (1.04–1.08) | 1.8e−08 | chr11:48234357..49873791 | FOLH1 OR4A47 OR4B1 OR4C3 OR4C5 OR4S1 OR4X1 OR4X2 TRIM49B TRIM64C |
| rs71639293 | chr5:92995013 | A | G | 1.07 (1.04–1.11) | 5.0e−05 | 1.04 (1.02–1.06) | 4.0e−05 | 1.05 (1.03–1.06) | 2.6e−08 | chr5:92995013..92995013 | FAM172A |
| rs16827974 | chr3:117837222 | A | G | 1.07 (1.04–1.10) | 3.3e−05 | 1.04 (1.02–1.05) | 6.8e−05 | 1.04 (1.03–1.06) | 3.1e−08 | chr3:117826733..117903064 | |
| rs17775184 | chr14:98647550 | T | C | 1.06 (1.03–1.10) | 9.6e−05 | 1.04 (1.02–1.05) | 5.2e−05 | 1.04 (1.03–1.06) | 4.7e−08 | chr14:98645610..98667928 |
Protein coding genes located in the immediate region of each SNP are reported.