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. 2021 Apr 1;6:46. doi: 10.1038/s41541-021-00302-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — BALB/c mice (n = 6) per group were vaccinated by intramuscular injection (20 µg per dose, two shots, 3-week prime-boost interval) with (NANP)₃ chemically coupled to Qβ virus-like particle and delivered with Matrix-M^™ adjuvant. A Standard curve ELISAs performed to determine the antibody response against (NANP)₆ peptide. Means are shown ± SD. B Mice were challenged by intravenous injection of 1000 PfCSP-replacement P. berghei sporozoites. The time to reach 1% blood-stage parasitaemia was calculated by linear regression from daily thin blood smears. P values from Log-rank tests in comparison to naïves are shown.