Table 1.

Stratified genetic covariance analysis on UKBB replication cohorts.

	Genetic Cova	s.e.	p-value	Proportion of genetic cov (%)	Proportion of SNPs (%)	Fold enrichment
LOGODetect	2.18e−4	6.65e−5	1.04e−3	11.50	1.15	10.02
$\mathrm{\rho }$-HESS	6.62e−4	3.16e−4	3.61e−2	30.00	20.12	1.49
coloc	−5.70e−5	2.30e−5	1.33e−2	−2.85b	0.34	−8.36b
gwas-pw	3.84e−5	6.54e−5	5.57e-1	1.92	1.61	1.20

^aGenetic Cov represents estimated genetic covariance of the identified regions using GNOVA.

^bGenetic covariance of regions identified by coloc has opposite sign compared to global genetic covariance, therefore the corresponding proportion of genetic covariance and fold enrichment are negative.