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. 2021 Apr 1;12(4):337. doi: 10.1038/s41419-021-03630-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A No difference in HOXC6 expression was observed between CRC and normal tissues by using TCGA samples. B HOXC6 was overexpressed in RCC but not in LCC compared to normal colon tissues based on TCGA samples. C Left: Western blot of fresh-frozen tissues from RCC and LCC showed that HOXC6 was overexpressed in RCC but not in LCC compared to paired adjacent normal colon tissues. Right: Adjusted mean gray values by control gray values of WB. D. KM plot showing that HOXC6 high-expression group had poor prognosis compared to the low-expression group in RCC. E The KM plot showed that there was no prognostic difference between the HOXC6 high-expression and low-expression groups in LCC. F KM plot showing that the HOXC6 high-expression group had a poor prognosis compared to the low-expression group in the ZUCI RCC samples (n = 100). G Representative images of the HOXC6 high-expression and low-expression groups. Scale bars indicate 100 µm. *: P < 0.05.