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. 2021 Apr 1;11:7380. doi: 10.1038/s41598-021-86265-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The GENI Score derived using 20,000 13,419 SARS-CoV-2 sequences from the United Kingdom (top) along with the corresponding epicurve. The inset epicurve displays the low level of cases in February indicting the outbreak was in the index phase. A high initial GENI score suggests cryptic viral transmission while a consistent GENI score indicates an increase in transmission as the pandemic progresses. This also indicates continued mutations increase viral genome diversification. While the epicurve varied after lockdown the GENI score consistently increased demonstrating continued production of genetic variation.