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. 2021 Apr 1;12(4):344. doi: 10.1038/s41419-021-03639-2

Fig. 3. LMP1 induces autophagy through BNIP3 in NPC cells.

Fig. 3

A After transfection with shBNIP3 and control for 24 h, the expression of BNIP3 and LC3І/ІІ in CNE1, CM, HNE2, HM, HK1, and KM cells by Western blots. B After transfection with shBNIP3 and control for 24 h, accumulation of GFP-LC3 puncta in NPC cells, Scale bar: 10 μm. Data are expressed as means ± S.D. of three experiments. *p < 0.05. C Immunohistochemical analysis was performed to detect the expression of LMP1, BNIP3, and LC3II in NPC patient tissues, and the correlations between LMP1, BNIP3, and LC3II were analyzed. UN untreated, CON negative control, Scale bar: 50 μm.