Fig. 7. LMP1-induced BNIP3 increases radioresistance of NPC in vivo.

The xenograft model was established using CM cells or CM-shBNIP3 cells. When the tumor volume reached 60–100 mm³, 6 Gy local irradiation was administered. A At the experimental end point, tumor xenografts were dissected and photographed. B Tumor volume was measured every 3 days after injection. C Tumor weight was measured at the experimental end point. *p < 0.05, ***p < 0.001. D Representative immunohistochemistry (IHC) staining of BNIP3 and LC3II expression in CM xenografts in the groups indicated in A. Scale bar: 50 μm. E A schematic illustration of the LMP1 promoting radioresistance by inducing autophagy through ERK/HIF1α/BNIP3 in NPC.