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. 2021 Apr 1;11:7362. doi: 10.1038/s41598-021-86826-7

Table 2.

Comparison of clinical outcomes after simultaneous bilateral TKA in both groups.

Opioid-based group (N = 28) Opioid-sparing group (N = 28) P values
VAS score (0–10 points)
Post-op 6 h, at rest 3.18 ± 3.06 2.36 ± 2.33 0.263
Post-op 12 h, at rest 3.44 ± 2.04 2.57 ± 1.48 0.074
Post-op 24 h, at rest 1.89 ± 2.04 1.92 ± 1.94 0.947
Post-op 24 h, with movement 5.18 ± 2.47 3.68 ± 2.48 0.027*
Post-op 48 h, at rest 1.36 ± 2.16 1.54 ± 1.69 0.732
Post-op 48 h, with movement 4.50 ± 2.19 3.57 ± 2.18 0.118
Post-op 72 h, at rest 1.64 ± 1.77 1.07 ± 1.44 0.190
Post-op 72 h, with movement 4.93 ± 2.23 3.50 ± 1.80 0.011*
Cumulative morphine dose (mg)
Post-op 24 h 20.99 ± 7.97 3.14 ± 2.62  < 0.001*
Post-op 48 h 35.05 ± 12.46 4.21 ± 3.68  < 0.001*
Post-op 72 h 45.69 ± 16.32 4.75 ± 4.33  < 0.001*
Continuous passive motion (°)
Post-op 24 h 89.07 ± 10.56 93.21 ± 9.83 0.135
Post-op 48 h 104.64 ± 8.39 108.79 ± 8.15 0.066
Post-op 72 h 114.46 ± 6.57 114.92 ± 5.72 0.779
Satisfaction rate (0–100 points) 77.22 ± 13.75 87.46 ± 10.09 0.003*

*p < 0.05.