Table 1.
Whole Gene ontology (GO) and pathway analysis of differentially expressed genes between CXCL12-day8 and control using DAVID tool. The cutoff for significance was set by P < 0.05, FE < 1.5. biological process (BP), cellular component (CC), and molecular function (MF).
| Category | Term | Count | P value | Fold Enrichment | FDR |
|---|---|---|---|---|---|
| Biological process (BP) | GO:0032355 ~ response to estradiol | 9 | 4.82E−03 | 3.421 | 0.08 |
| Biological process (BP) | GO:0045909 ~ positive regulation of vasodilation | 6 | 0.00287 | 6.062 | 0.0485 |
| Biological process (BP) | GO:0007155 ~ cell adhesion | 25 | 0.00203 | 1.979 | 0.0345 |
| Biological process (BP) | GO:0050728 ~ negative regulation of inflammatory response | 9 | 0.00191 | 3.971 | 0.0324 |
| Biological process (BP) | GO:0010628 ~ positive regulation of gene expression | 23 | 8.10E−04 | 2.213 | 0.0139 |
| Biological process (BP) | GO:0006955 ~ immune response | 18 | 8.05E−04 | 2.541 | 0.0138 |
| Biological process (BP) | GO:0007166 ~ cell surface receptor signaling pathway | 16 | 6.37E−04 | 2.805 | 0.0109 |
| Biological process (BP) | GO:0010907 ~ positive regulation of glucose metabolic process | 6 | 1.67E−04 | 10.97 | 0.0029 |
| Biological process (BP) | GO:0071396 ~ cellular response to lipid | 6 | 2.81E−05 | 15.36 | 0.0005 |
| Cellular component (CC) | GO:0005576 ~ extracellular region | 125 | 9.5E−25 | 2.665 | 1.0−23 |
| Cellular component (CC) | GO:0005615 ~ extracellular space | 80 | 4.66E−09 | 1.988 | 6.0E−08 |
| Cellular component (CC) | GO:0005578 ~ proteinaceous extracellular matrix | 23 | 4.47E−05 | 2.721 | 6.0E−04 |
| Cellular component (CC) | GO:0009897 ~ external side of plasma membrane | 19 | 0.00228 | 2.24 | 0.031 |
| Molecular function (MF) | GO:0036094 ~ small molecule binding | 9 | 1.30E−06 | 10.67 | 2.0E−05 |
| Molecular function (MF) | GO:0008236 ~ serinE-type peptidase activity | 14 | 3.84E−04 | 3.26 | 0.006 |
| Molecular function (MF) | GO:0008233 ~ peptidase activity | 26 | 0.0026 | 1.91 | 0.037 |
| Molecular function (MF) | GO:0008201 ~ heparin binding | 11 | 0.0067 | 2.763 | 0.094 |
| Molecular function (MF) | GO:0048020 ~ CCR chemokine receptor binding | 5 | 0.0059 | 6.773 | 0.083 |
| Molecular function (MF) | GO:0030246 ~ carbohydrate binding | 15 | 0.0031 | 2.484 | 0.044 |
| Molecular function (MF) | GO:0005009 ~ insulin-activated receptor activity | 5 | 2.8E−04 | 14.59 | 0.004 |