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. 2021 Apr 1;12:2037. doi: 10.1038/s41467-021-22236-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — PLSDA scores (a) and loadings (b) plots for the children (n = 12) (orange) and elderly (n = 12) (dark blue) with an Elastic-Net-selected 18-feature signature (100.00% calibration accuracy, 91.37% cross-validation accuracy). Hierarchical clustering was performed using the 18-feature signature for the children and elderly cohorts (c). S1-specific antibody engagement of FcγRIIaR (d) and FcγRIIaR (e) were amongst the strongest features in the PLSDA loadings plot (b) and are significantly elevated in children (Supplementary Data 5 describes all comparisons between children and elderly). THP-1 monocyte cell line antibody-mediated uptake of spike-coated bead assay (f) and spike-expressing target cell assay (g). Statistical significance was calculated using the two-tailed Mann-Whitney U test and exact p-values were reported. S1-specific antibody engagement of FcγRIIaR, FcγRIIaR and the two THP-1 SARS-CoV2 spike Fc effector assays highly correlate with each other, as measured by two-tailed Spearman correlation (h). Multiplex assays were repeated in duplicates.