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. 2021 Apr 1;11:7360. doi: 10.1038/s41598-021-86522-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Oxidative stress in CD+ keratocytes up-regulates the IL-8 expression. (A) CD/total mtDNA ratios in 45 human subjects quantified by multiplex-qPCR. 26 values were zero and are not included on the graph. (B) Flow cytometric detection of DCFH-DA and mitoSOX signal in CD+/− keratocytes (n = 3). (C) mRNA expression of IL-8 in CD+/− keratocytes. Cells either treated with 10 μM mitoTEMPO (Mito), or not, for 24 h (n = 3). (D) Quantification of secreted IL-8 level using ELISA. Cells treated, or not treated, with 10 μM mitoTEMPO for 24 h (n = 3). Values are means ± SD. n.s. (not significant); *P < 0.05, **P < 0.01.