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. 2021 Apr 1;11:7316. doi: 10.1038/s41598-021-86585-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Floxed Myd88 (Myd88^lox/lox) were bred with alpha actin merCREmer mice (HSA-Cre^ERT2/−) to form homozygote floxed skmMyd88^+/+ mice with a heterozygote HSA-Cre^Ert/+/−. Mice were then randomly divided into raloxifene treatment (to induce Cre) or vehicle treatment to produce a total of 2 experimental groups. A previous time-matched study reported results of the Cre mouse strain (Laitano et al. 2020). (b) Genotyping PCR of the skmMyd88KO mice in four representative muscles Sol (slow oxidative soleus), Dia (diaphragm), Gas (gastrocnemius, mixed fiber type) TA (tibialis anterior; fast muscle) and four other tissue types: Hrt (heart), Kid (Kidney), Spl (Spleen) and Liv (Liver). Brightness and contrast adjustments were applied uniformly across all lanes of the PCR gel. Mouse image from https://cliparting.com/mouse-clipart/.