Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 1;11:7347. doi: 10.1038/s41598-021-86762-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

(a)–(c) In vitro anti-cancer efficiency of PTXNR-TTZ ADNs: The cytotoxic effects of PTXNR-TTZ (closed circle), PTXNR (triangle), PTX solution (diamond), and TTZ (square) on the growth of (a) BT-474, (b) SK-BR-3, and (c) MDA-MB-231 cells. Each experiment was replicated at least n = 6 times, and the average data is presented with mean ± standard deviation. The p values are given in SI Table 3. (d)–(f) The nuclear morphology of apoptotic cells stained with Hoechst 33342: Cells transfected with PTXNR-TTZ were stained with Hoechst 33342 72 h post-transfection and observed under a fluorescence microscope. The combined treatment with PTXNR-TTZ displayed the increased amount of nuclear fragmentation in (d) BT-474, (e) SK-BR-3, and (f) MDA-MB-231 cells. Untreated control cells remained uniformly stained with round and undamaged nuclei. The figures represent one of three independent experiments. (g)–(i) Combination index (C.I.) analysis of PTXNR-TTZ ADNs: The C.I. plot as a function of each fraction of cells affected by PTXNR-TTZ particles in (g) BT-474, (h) SK-BR-3, and (i) MDA-MB-231 cells. A C.I. value = 1; additive effect, < 1; synergistic effect, > 1; antagonistic effect.