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. 2021 Apr 1;11:7403. doi: 10.1038/s41598-021-86788-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ZEA increased the expression of proliferation marker. RT-qPCR analysis of (A) CCND1 and (B) Ki67 mRNA expression of SW480 and HT29 incubated with 3 μM ZEA with or without G15 (GPER antagonist). (C) cAMP production induced by 3 μM ZEA in the absence or presence of 5 μM G15. cAMP production was analysed by comparing the cAMP production to control group as 100%. (D) Western blot analysis of CCND1 protein expression, (E) Ki-67 expression was determined by immunofluorescence staining for Ki67 (green) along with DAPI for DNA (blue). Scale bar, 20 μm. Results shown are mean ± SEM, with n = 3. *p < 0.05 and **p < 0.01.