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. 2021 Apr 1;12(4):347. doi: 10.1038/s41419-021-03641-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Expression levels of LDHA mRNA in 20 paired normal tissues and primary tumor tissues. B Expression levels of LDHA in eight paired normal tissues and primary tumor tissues. C LDHA was found to be mainly located in the cytoplasm of PTCs. Representative IHC images of weak staining, moderate staining, and strong staining were shown. D, E Kaplan–Meier survival analysis showed that high LDHA levels were significantly associated with poor RFS and OS in PTC patients. All *p < 0.05, **p < 0.01, ***p < 0.001.