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. 2021 Apr 1;12(4):347. doi: 10.1038/s41419-021-03641-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A B-CPAP cells were transfected with two different LDHA knockdown plasmids. Representative images of migration/invasion are shown. B Representative images of migrating/invading KTC-1 cells expressing LDHA. C In vivo bioluminescence images of B-CPAP cells transfected with the LDHA knockdown plasmid. D The mean fluorescence intensity of the LDHA knockdown group was significantly lower than that of the control group. E Representative images of lung metastatic foci. The number of lung metastatic foci was significantly lower in LDHA knockdown group than in control group. F Representative images of liver metastatic foci. The number of liver metastatic foci was significantly lower in LDHA knockdown group than in control group. The data are presented as the mean ± SD. All *p < 0.05, **p < 0.01, ***p < 0.001.