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. 2021 Apr 1;12(4):347. doi: 10.1038/s41419-021-03641-8

Fig. 4. LDHA promotes the proliferation and inhibits the apoptosis of PTC cells in vitro and in vivo.

Fig. 4

A–C CCK-8 assays and D–F colony formation assays showed that LDHA knockdown or inhibition significantly suppressed cell proliferation in B-CPAP cells and that the overexpression of LDHA promoted cell proliferation in KTC-1 cells. G, H Flow cytometry indicated that LDHA knockdown or inhibition significantly induced cell apoptosis in B-CPAP cells. I Five representative tumors from LDHA knockdown cells are shown. Tumor volumes J are presented with growth curves, and tumor weights K were measured. L Representative IHC images of cleaved caspase 3 expression and Ki-67 staining in xenografted tumor specimens of control and LDHA knockdown mice are shown. The data are presented as the mean ± SD. All *p < 0.05, **p < 0.01, ***p < 0.001.