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. 2021 Apr 1;12:2031. doi: 10.1038/s41467-021-22200-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Relative proportions of murine viruses in the virome of lung cancer PDX cells are significantly higher than in the cells from the primary lung cancer samples as measured by single-cell RNA-Seq (PDX: n = 1147; non-PDX: n = 152). b, c Viral reads from single-cell sequencing of PDX-derived tumor cells cover the entire genomic region of MLV. d No single-cell sequencing reads from non-PDX control samples were observed or mapped to the viral genome. e The single-cell sequencing reads that can be mapped to the mouse reference genome are very low in both PDX-derived tumor cells and non-PDX control cells (PDX: n=9; non-PDX: n = 152). For box plots in (a) and (e), Box limits: 25th and 75th percentiles; center line: median; whiskers: 1.5x interquantile range from box limits; dots: outliers. Source data for a and e are provided in Source Data File.