Fig. 4. Chimeric sequence reads containing both viral (blue) and human (orange) genome sequences were identified from PDX RNA-Seq reads for six tumor types, indicating the integration of murine viral genome.

The chromosome, the gene name and the exon within which the integration site located is also provided. a Breast Cancer. Integration site is on chromosome 4, within the fifth exon of the MSM01 gene which has five exons. b GBM. Integration site is on chromosome 8, within the 18th exon of the RECQL4 gene which has 22 exons. c Lung Cancer. d Ovarian Cancer. e Bladder Cancer. f Colon Cancer. The genomic position and the orientation from human and virus genome are marked. The depth of coverage is labeled between reads. The detailed information is provided in Supplementary Data 2.