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. 2021 Mar 19;9:651406. doi: 10.3389/fcell.2021.651406

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Copyright © 2021 Zheng, Tian, Zhou, Xiao, Liu, Liu, Wang, Fan, Zheng, Tan, Xue, Gao, Li and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alterations of signaling in hot and cold tumors. (A) Immune infiltration in hot and cold tumors analyzed by TIMER. (B) Differentially expressed genes between hot and cold tumors. (C,D) Gene Ontology (GO) enrichment analysis in hot and cold tumors. (E,F) Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis in hot and cold tumors. ****p < 0.001; ns, not significant.