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. 2021 Mar 19;9:651406. doi: 10.3389/fcell.2021.651406

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Copyright © 2021 Zheng, Tian, Zhou, Xiao, Liu, Liu, Wang, Fan, Zheng, Tan, Xue, Gao, Li and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of hub and prognostic-related genes. (A) Protein–protein interaction (PPI) network of upregulated genes in the hot tumor. (B) PPI network of downregulated genes in the hot tumor. (C,D) Least absolute shrinkage and selection operator (LASSO) and partial likelihood deviance coefficient profiles of the selected genes. (E) Multivariate Cox analysis showed the hazard ratios (HRs) of selected genes with forest plots.