Table 2.

Linear regression for association of COVID-19 disease with ovarian reserve AMH.

	Univariate linear analysis
	β#		95% CI			P-value
Age	−0.734		−0.212	−0.166		<0.001***
Menstrual status※	0.427		0.717	1.357		<0.001***
COVID-19	−0.162		−1.161	−0.121		0.016*
Gravidity	−0.298		−0.435	−0.168		<0.001***
Parity	−0.331		−1.069	−0.465		<0.001***
BMI	−0.1		−0.155	0.029		0.176
Menarche	−0.049		−0.222	0.105		0.481
Smoking	−0.002		−1.007	0.974		0.974
Benign gynecological disease	−0.054		−1.272	0.607		0.486
Gynecological operation history	−0.124		−1.127	0.109		0.106
Variable	Multivariate hierarchical linear regression analysis
	Step 1 (β)	P-value	Step 2 (β)	P-value	Step 3 (β)	P-value
Step 1
Age	−0.671	<0.001***	−0.606	<0.001***	−0.567	<0.001***
Gravidity	−0.095	0.171	−0.099	0.146	−0.116	0.081
Parity	−0.017	0.807	−0.006	0.925	0.045	0.506
Step 2
Menstrual status※			0.145	0.017*	0.186	0.002**
Step 3
COVID-19					−0.191	0.001***
F	58.560	<0.001***	5.793	0.017*	12.200	0.001***
R2	0.514		0.531		0.563
ΔR2			0.016		0.032

Univariate and multivariate hierarchical linear regression models were used to assess the relationship between COVID-19 clinical characteristics and AMH; Only the variables showing statistical significance in univariate analysis were included in the multivariate hierarchical linear analysis.

^#β = standardized regression coefficient.

^※Menstrual status including amenorrhea ≥3 months, irregular menstrual cycle, and regular menstrual cycle, as ordered rank variable.

^*P < 0.05

^**P < 0.01

^***P < 0.001.