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. 2021 Mar 19;8:624302. doi: 10.3389/fmolb.2021.624302

FIGURE 1.

FIGURE 1

(A) PHF protofilament based on the cryo-EM R3-R4 structure of residues V306-F378 (PDB ID entry 503 L). We used ten total chains labelled A-J arranged as five paired filaments. The C-shaped core structure has eight β sheets labelled β1-β8. (B) SF protofilament based on the cryo-EM R3-R4 structure of residues V306-F378 (PDB ID entry 5O3T). The SF structure has the same eight β sheets labelled β1-β8 but a different orientation of paired filaments. A rendered view of the secondary structure is shown at the bottom with the β sheets individually colored.