Table 1.
Overview of assessment instruments by time-periods.
| Instrument | Purpose | Basal | 6-Month | Year 2 | Year 5 | Year 10 | Year 15 | Year 20 | Follow-up | |
|---|---|---|---|---|---|---|---|---|---|---|
| Demographics | CASH | Confounders (age, gender, education) | X | X | ||||||
| Familial-genetic factors | PRS | SZ, BIP, Cognition | X | |||||||
| FLS | Familial load of SZ, BIP and MDD | X | X | |||||||
| Distal antecedents | L-M | Obstetric complications | X | |||||||
| Register | Season of birth | X | ||||||||
| NDS | Neurodevelopmental delay | X | ||||||||
| Intermediate antecedents | CASH | Childhood adjustment | X | |||||||
| GFES | Childhood adversity | X | ||||||||
| C-SPAS | Scholastic performance | X | ||||||||
| CASH | Adolescence adjustment | X | ||||||||
| CASH | Deterioration in adjustment | X | ||||||||
| GAF | Premorbid global functioning | |||||||||
| Proximal antecedents | DSM-III | Acute psychosocial stressors | X | |||||||
| CASH, ASS | Type and severity of drug abuse | X | ||||||||
| Illness-onset factors | CASH | Duration of untreated psychosis | X | |||||||
| CASH | Mode of onset | X | ||||||||
| CASH | Age at illness onset | X | ||||||||
| Treatment response | CGI-EI, RSWG | Early treatment response at discharge | X | |||||||
| RSWG | 6-Month treatment response | X | X | X | X | X | X | X | ||
| Illness-course variables | CASH, DSM-5 | Diagnostic class of psychotic disorder | X | X | X | X | X | X | X | X |
| CASH, | Treatment history | X | X | X | X | X | X | X | X | |
| CASH, ASS | Drug abuse | X | X | X | X | X | X | X | X | |
| CASH | Service use | X | X | X | X | X | X | X | X | |
| CASH | No. and timing of relapses | X | X | X | X | X | X | X | ||
| CASH | No. of suicide attempts | X | X | X | X | X | X | X | X | |
| CASH | Typification of illness course | X | X | X | X | X | X | X | X | |
| CASH | Lifetime symptom load | X | X | X | X | X | X | |||
| Lifetime comorbidity | Register | Other mental disorders | X | X | X | X | X | X | ||
| Register | Medical illnesses and treatments | X | ||||||||
| Psychopathology | CASH | Psychotic and mood symptoms | X | X | X | X | X | X | X | X |
| PANSS | Lack of insight | X | ||||||||
| SDS | Deficit symptoms | X | X | X | X | X | X | |||
| BADDS | Lifetime mood and psychotic symptoms | X | ||||||||
| Motor dysfunction | SARS | Parkinsonism | X | X | ||||||
| AIMS | Dyskinesia | X | X | |||||||
| BARS | Akathisia | X | ||||||||
| MRS | Motor abnormalities | X | X | |||||||
| NES | Neurological soft signs | X | X | |||||||
| Psychosocial functioning | GAF | Global symptoms and functioning | X | X | X | X | X | X | X | X |
| SOFAS | Social and occupational functioning | X | X | X | X | X | X | |||
| WHO-DAS | Four areas of functioning | X | X | X | X | X | X | |||
| FAST | Six areas of functioning | X | X | X | X | X | X | X | ||
| Symptomatic remission | CASH | RSWG criteria | X | X | X | X | X | X | X | |
| Functional remission | GAF | GAF score ≥61 | X | X | X | X | X | X | X | |
| Personal recovery | PRQ-15 | Self-reported recovery | X | |||||||
| Quality of life | SQLS | Self-reported quality of life | X | |||||||
| EUROQOL | Self-reported health dimensions | X | ||||||||
| Cognition | SCIP | Brief cognitive screening | X | |||||||
| MoCA | Brief neuro-cognitive screening | X | ||||||||
| MCCB | Extensive cognitive battery | X | ||||||||
| Metabolic syndrome | AHA criteria | Cardio-metabolic risk factors | X |
AHA: American Heart Association; AIMS: Abnormal Involuntary Movements Scale; ASS: Addition Severity Scale BADDS: Bipolar Dimension Disorder Scale; BARS: Barnes Akathisia Rating Scale; BIP: Bipolar Disorder; CASH: Comprehensive Assessment of Symptoms and History; CGI-EI: Clinical Global Impression Efficacy Index; C-SPAS: Cannon-Spoor Premorbid Adjustment Scale; EUROQOL: European Quality of Life Group; FAST: Functioning Assessment Short Test; FLS: Familial Load Score; GAF: Global Assessment of Functioning; GFES: Global Family Environment Scale; L-M: Lewis-Murray Obstetric Complications Scale; MDD: Major Depressive Disorder; MoCA: Montreal Cognitive Assessment; MRS: Modified Rogers Scale; NDS: Neurodevelopmental Scale; NES: Neurological Evaluation Scale; PANSS: Positive and Negative Syndrome Scale; PRQ-15: Questionnaire about the Process of Recovery; PRS: Polygenic Risk Score; RSWG: Remission in Schizophrenia Working Group; SARS: Simpson-Angus Rating Scale; SDS: Schedule for the Deficit Syndrome; SOFAS: Social and Occupational Functioning Assessment Scale; SQLS: Schizophrenia Quality of Life; SZ: Schizophrenia; WHO-DAS: World Health Organization-Disability Assessment Schedule. Assessments at year 2, 5, 10, 15 and 20 were made using a retrospective life charting methodology.