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. 2021 Mar 19;12:642735. doi: 10.3389/fneur.2021.642735

Figure 2.

Figure 2

In silico prediction of microRNAs binding 3′UTR PHOX2B. (A) Target scan release showing microRNA binding the 3′UTR of the PHOX2B gene; in the upper part of the figure, the color scale indicates the strength of the prediction, based on the specificity of the seed (violet: 8mer; red: 7mer-m8; cyan: 7mer-A1; green: non-canonical). In the lower part of the figure, the sequences surrounding the proximal, less conserved miR204 site (P-204) and the distal, more conserved miR204 site (D-204) are shown. The c.*161G>A position is boxed in yellow. (B) The table shows results obtained by the custom prediction option MicroRNA Target Prediction Database (miRDB); results show the different miR-204 affinity in the presence of the c.*161 G and A alleles. In the two columns, the allele and the score of miR-204 binding are shown.