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. 2021 Mar 19;12:642735. doi: 10.3389/fneur.2021.642735

Figure 3.

Figure 3

Effects of rs114290493 alleles on miR-204 mediated expression modulation. (A) The effect of the 219-bp subcloned region on the Luciferase stability is shown in the presence of both G and A alleles; values are expressed as percentage of the empty pmiRGlo vector expressed as 100 and are the mean of three independent experiments performed in triplicate ±SD. Asterisks (*) indicate statistically significant values (Student's t-test, p < 0.05) obtained by comparing each allele with respect to the empty vector (*p-value G: 0.015; p-value A: 0.019). (B) The bar graph shows the Luciferase activity induced by addition of miR-204 as percentage of the value obtained in the absence of miR-204, referred as 100. Values are the mean of three independent experiments performed in triplicate ±SD. Asterisk (*) indicates statistical significance (Student's t-test, p < 0.05) obtained by comparing each allele added vs. not added with miR-204 (*p value A: 0.0001).