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Functional annotation and enrichment analysis. (A) Functional classifcation and (B) KEGG pathway assessment of the source genes of differential circRNAs. (C) GO annotation and (D) KEGG enrichment of mRNAs in circRNA–miRNA–mRNA regulatory network. (E) Expression heatmap and (F) significantly enriched KEGG pathways of genes shared between DE circRNA source genes and DE mRNAs. 3M, 1Y, and 3Y refer respectively to 3-month-old, 1-year-old, and 3-year-old.
