FIGURE 3.

The signaling pathways involved in the effects of hydrogen sulfide on endoplasmic reticulum stress. H₂S exerts neuroprotective effect by inhibiting 6-hydroxydopamine induced ERS through activating Akt-Hsp90 signaling pathway; H₂S plays an antidepressant role through inhibiting ERS by activating BDNF-TrkB signaling pathway; H₂S improves the survival rate of transplanted mesenchymal stem cells and IVDD by suppressing ERS-induced apoptosis through activating PI3K/Akt signaling pathway; H₂S alleviates VILI by inhibiting ERS through suppressing NF-κB/MAPK signaling pathway. ERS, endoplasmic reticulum stress; Akt-Hsp90, protein kinase B-heat shock protein 90; BDNF-TrkB, brain derived neurotrophic factor-tyrosine kinase receptor type 2; PI3K/Akt, phosphatidylinositol 3 kinase/protein kinase B; NF-κB/MAPK, nuclear factor kappa-B/mitogen-activated protein kinases; VILI, ventilator-induced lung injury; IVDD, intervertebral disc degeneration.