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. 2021 Mar 19;9:650431. doi: 10.3389/fcell.2021.650431

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Copyright © 2021 Cai, Qi, Yao, Yao, Jing, Liao and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circ-FOXP1 serves as a specific marker of undifferentiated MSC and are source- and gender-independent. (A) MSCs were induced to differentiate into osteocytes, chondrocytes, and adipocytes. (B) Images of initiation status and differentiation results of MSCs at 21 days. (C) CircFOXP1 expression in different cells. (D) CircFOXP1 expression in different tissues. (E) The relative transcriptional level of circFOXP1 as MSCs differentiated into different cells. (F,G) CircFOXP1 expression in MSCs are source- and gender-independent. WJ-MSCs: Wharton’s jelly MSCs; AD-MSCs, Adipose tissue MSCs; BM-MSCs, Bone marrow MSCs; CB-MSCs, Cord blood MSCs. (B) scale bar = 200 μm. Data in (C,D,F) are shown as means ± standard error of the mean (n = 3); ns, not significant; *P < 0.05, **P <0.01. Reprinted from Cherubini et al. (2019).