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. 2021 Mar 19;12:578548. doi: 10.3389/fimmu.2021.578548

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Copyright © 2021 Chen, Liu, He, Sun, Wang, Chen and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Peripheral mucosal-associated invariant T cells (MAIT) cells from patients with primary biliary cholangitis (PBC) decreased significantly. (A) Representative plots of fluorescence-activated cell (FACS) (left), summary frequency (right), and absolute numbers (bottom) of peripheral CD3⁺CD8⁺CD161^highTCRVα7.2⁺MAIT cells from patients with PBC (n = 55) and healthy controls (HCs) (n = 69). (B) Correlation of peripheral MAIT cell population with laboratory parameters in patients with PBC (n = 55). Data were expressed as mean ± SD. The value of ****p < 0.0001 by the Student's t-test. Correlations were calculated using the Spearman's correlation analysis.