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. 2021 Mar 19;12:578548. doi: 10.3389/fimmu.2021.578548

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Copyright © 2021 Chen, Liu, He, Sun, Wang, Chen and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation potential of MAIT cells from patients with PBC. Peripheral blood mononuclear cells (PBMCs) were stimulated with phorbol myristate acetate (PMA) and ionomycin or anti-CD3 and anti-CD28 antibodies. Representative FACS plots (left) and summary graphs (right) of (A) CD38 (upper, PBC = 8, HC = 11) and CD69 (bottom, PBC = 24, HC = 42) expression on MAIT cells from patients with PBC and from HCs. (B) Interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α), (C) Granzyme B, (D) perforin, and (E) IL-17A of MAIT cells from patients with PBC (n = 6) and from HCs (n = 6). Gray plots represent fluorescence minus one (FMO) control. The data were expressed as mean ± SD. NS, not statistically significant; *p < 0.05, ***p < 0.001, and ****p < 0.0001 by Student's t-test.