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. 2021 Mar 19;12:578548. doi: 10.3389/fimmu.2021.578548

Figure 3.

Figure 3

MAIT cells in patients with PBC accumulate in the liver via CXCL12–CXCR4 pathway. (A) Immunofluorescence staining of MAIT cells (arrow) in the liver of patients with PBC (n = 8) and in patients with hepatic hemangioma (Controls, n = 8). Magnification: ×400, scale bar: 50 μm. (B) Representative FACS plots (upper) and summary graphs (bottom) of CXCR4 (n = 14), CCR10, CCR6, CXCR6, and CX3CR1 on MAIT cells from patients with PBC and from HCs. (C) Immunohistochemistry staining of CXCL12 in the liver of patients with PBC (n = 8) and in Controls (n = 8); magnification: ×400, scale bar: 50 μm. (D) Chemotaxis rate of MAIT cells stimulated with CXCL12 (and) AMD3100 from patients with PBC (n = 5) and from HCs (n = 6). Gray plots represent FMO control. The data were expressed as mean ± SD. NS, not statistically significant; *p< 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 by the Student's t-test and the ANOVA analysis.