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. 2021 Mar 19;8:646412. doi: 10.3389/fmolb.2021.646412

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Copyright © 2021 Zhuang, Zhuang, Zhou, Huang, Gui, Lai and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Engineered CRISPR/Cas13d sensing hTERT selectively induced bladder cancer cell apoptosis. Engineered CRISPR/Cas13d sensing hTERT have no effects on apoptosis in HFF (A). However, cell apoptosis was significantly increased by engineered CRISPR/Cas13d sensing hTERT in bladder cancer 5637 (B) and T24 (C) cells.