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. 2021 Mar 19;8:643178. doi: 10.3389/fmolb.2021.643178

TABLE 1.

Potential extracellular substrates specific or common of ADAMTS2 and/or ADAMTS14.

Name TS2 TS14 TS2TS14 Name TS2 TS14 TS2TS14
Inter alpha-trypsin inhibitor 1.2 ± 0.7 1.9 ± 0.7 1.6 ± 0.5 Galectin-1 1.3 ± 0.3 1.9 ± 0.4 2.1 ± 0.4
AE-binding protein 1 0.7 ± 0.2 2.0 ± 0.5 1.2 ± 0.3 Galectin-7 2.0 ± 0.6 2.8 ± 0.8 4.8 ± 1.4
Alpha-2-HS-glycoprotein 0.7 ± 0.3 2.2 ± 1.3 0.9 ± 0.3 Gc-globulin 1.7 ± 0.8 4.1 ± 2.0 6.0 ± 3.7
Alpha-2-macroglobulin 1.7 ± 1.0 2.0 ± 0.6 2.2 ± 0.6 Gelsolin 2.6 ± 0.7 2.4 ± 0.9 5.0 ± 1.7
Annexin-8 6.4 ± 2.2 5.5 ± 1.9 15.0 ± nd a H2-Q9 1.9 ± 1.3 2.7 ± 1.1 2.9 ± 1.1
Apolipoprotein A-I 2.7 ± 1.8 3.3 ± 1.9 4.5 ± 1.8 Hemopexin 1.0 ± 0.4 1.9 ± 0.5 1.5 ± 0.5
Apolipoprotein H 1.6 ± 0.8 2.6 ± 1.2 2.3 ± 0.8 Ig gamma-2B 1.8 ± 0.5 2.3 ± 0.8 3.5 ± 1.2
Beta-globin 2.2 ± 0.6 2.9 ± 1.1 6.7 ± 3.3 Ig gamma-3 1.1 ± 0.4 1.9 ± 0.4 1.8 ± 0.4
Biglycan 2.8 ± 2.4 3.0 ± 1.6 3.6 ± 1.8 Ig kappa chain V-V 1.2 ± 0.8 5.1 ± 2.7 2.9 ± 1.1
Carboxypeptidase A3 1.6 ± 0.4 2.1 ± 0.5 3.2 ± 1.1 Kallikrein j 2.0 ± 0.8 2.4 ± 0.6 5.1 ± 0.6
Cathepsin B heavy chain 1.3 ± 0.6 1.9 ± 0.6 1.6 ± 0.3 Kininogen-1 2.2 ± 0.5 2.9 ± 0.6 5.5 ± 0.2
Cathepsin H 1.2 ± 0.6 2.4 ± 0.8 2.0 ± 0.6 Lumican 1.6 ± 0.7 2.6 ± 1.3 2.3 ± 0.4
Cathepsin S 1.0 ± 0.5 2.2 ± 0.7 1.5 ± 0.4 Mast cell protease 4 1.5 ± 0.2 1.7 ± 0.2 2.4 ± 0.5
Caveolin-1 2.0 ± 0.8 3.1 ± 1.4 3.1 ± 0.0 MIF 1.1 ± 0.6 2.7 ± 1.1 1.8 ± 0.5
Cavin-1 2.1 ± 0.4 3.5 ± 0.9 8.7 ± 0.4 Myelin protein zero 1.6 ± 0.7 2.1 ± 1.1 1.7 ± 0.4
Coagulation factor XIIIa 2.5 ± 1.0 3.8 ± 1.5 7.8 ± nd a Osteoglycin 2.3 ± 0.7 2.3 ± 0.9 4.5 ± 1.6
Collagen alpha-1(I) chain 4.2 ± 0.5 1.7 ± 0.2 6.8 ± 1.0 p24 gamma-1 2.1 ± 1.1 3.3 ± 1.7 1.4 ± 1.0
Collagen alpha-1(III) chain 3.7 ± 2.2 2.8 ± 1.3 5.8 ± 2.7 p35/Annexin A1 2.7 ± 1.2 2.7 ± 0.9 7.4 ± 3.7
Collagen alpha-1(IV) chain 1.6 ± 0.6 1.8 ± 0.6 2.2 ± 0.4 p36/Annexin A2 2.7 ± 1.2 2.7 ± 0.9 7.4 ± 3.7
Collagen alpha-1(V) chain 3.9 ± 1.7 4.1 ± 1.6 9.3 ± 0.8 PCPE-1 2.2 ± 0.4 1.9 ± 0.4 3.6 ± 0.5
Collagen alpha-1(VI) chain 2.2 ± 0.8 1.9 ± 0.6 3.4 ± 0.9 PDI A6 1.8 ± 0.7 2.1 ± 0.7 2.9 ± 0.9
Collagen alpha-1 (XIV) chain 3.6 ± 0.7 2.3 ± 0.5 8.2 ± 2.5 Periostin 1.0 ± 0.5 2.2 ± 0.8 1.3 ± 0.4
Collagen alpha-2(I) chain 3.1 ± 0.7 1.6 ± 0.2 4.6 ± 0.6 Proapolipoprotein A-II 3.5 ± 2.5 4.9 ± 3.2 11.9 ± 7.9
Collagen alpha-2(V) chain 1.8 ± 0.3 1.7 ± 0.3 2.8 ± 0.3 Prolargin 2.9 ± 0.9 2.6 ± 0.8 5.8 ± 1.3
Collagen alpha-2(VI) chain 2.5 ± 0.7 2.2 ± 0.6 4.1 ± 0.0 Protein unc-80 homolog 1.8 ± 0.6 2.0 ± 0.2 3.5 ± 1.4
Collagen alpha-3(VI) chain 4.7 ± 1.3 2.1 ± 0.6 8.0 ± 1.2 Serpin A1c 1.1 ± 0.3 2.4 ± 1.0 2.1 ± 0.5
Complement C3 1.8 ± 1.4 4.3 ± 3.4 2.3 ± 0.8 Serpin A1d 0.8 ± 0.5 2.8 ± 1.3 1.0 ± 0.4
Complement C4-B 0.3 ± 0.1 2.7 ± 1.0 0.6 ± 0.2 Serpin B6 4.7 ± 2.5 3.9 ± 2.4 8.0 ± 1.9
Complement factor B 0.9 ± 0.2 2.0 ± 0.4 1.8 ± 0.5 Protein serpinb6e 1.3 ± 0.3 2.3 ± 0.6 2.5 ± 0.1
Complement factor H 1.0 ± 0.3 1.8 ± 0.5 1.7 ± 0.6 Serum albumin 3.2 ± 1.7 4.2 ± 2.4 12.6 ± 9.7
Corneodesmosin 1.5 ± 0.4 1.7 ± 0.4 2.2 ± 0.4 Siderophilin 2.2 ± 0.7 2.8 ± 1.1 5.2 ± 2.5
Cystatin-3 2.4 ± 0.6 2.7 ± 0.8 7.0 ± 3.7 Stromelysin-1/MMP3 0.4 ± 0.1 1.5 ± 0.3 0.5 ± 0.1
Dermatopontin 2.0 ± 0.4 1.6 ± 0.2 3.1 ± 0.6 Susd 4 2.3 ± 0.7 2.4 ± 1.1 3.9 ± 1.1
Dermokine 1.1 ± 0.3 1.4 ± 0.3 1.4 ± 0.2 Transcobalamin II 0.8 ± 0.5 2.2 ± 1.1 0.8 ± 0.2
a

nd: not determined.

The 68 extracellular and cell surface potential substrates are reported together with the average P/C ratio from at least two experiments for ADAMTS2, ADAMTS14 or ADAMTS2 and ADAMTS14. When several peptides were identified for a protein, the ratios from the peptide giving the highest value are reported for illustration. All the peptides and ratios are reported in supplemental.