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. 2021 Mar 19;11:620213. doi: 10.3389/fonc.2021.620213

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Copyright © 2021 Yu, Tian, Yang, Liu, Wang and Gong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of SNORA47 significantly inhibited the tumor growth of NSCLC in vivo. A549 cells were subcutaneously injected into nude mice to mimic NSCLC in vivo. SNORA47 shRNA1 or vector control was directly injected into the tumors. (A) Tumor volumes were assessed once a week. (B) Tumor tissues of mice were collected at the end of the study. (C) Tumor weights of mice were investigated. (D) The level of SNORA47 in mice was investigated by RT-qPCR. (E) The proliferation of NSCLC cells was detected by Ki67 staining. (F) The protein levels of p-Akt and p-ERK in tissues of mice were measured by IHC staining. **P < 0.01 compared to control.