Table 5.
TMEM16A mRNA and protein expression according to KRAS/NRAS/BRAF mutation status in CRCs.
| TMEM16A mRNA expression (qPCR) | TMEM16A protein expression (IHC) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| n | Negative | Positive | P | n | Negative | Positive | P | ||
| KRAS (codon 12/13) | MT | 29 | 6 | 23 | 0.593a | 32 | 19 | 13 | 0.017a |
| WT | 38 | 10 | 28 | 48 | 40 | 8 | |||
| NRAS (codon12/13/59/61/117/46) | MT | 1 | 0 | 1 | 1.000b | 3 | 2 | 1 | 1.000b |
| WT | 66 | 16 | 50 | 77 | 57 | 20 | |||
| BRAF (condon 600) | MT | 1 | 1 | 0 | 1.000b | 0 | 0 | 0 | 1.000b |
| WT | 66 | 16 | 50 | 80 | 59 | 21 | |||
MT means mutant type. WT means wild type.
a
Chi-square test.
b
Fisher's exact test.
Bold values means P < 0.05, which indicate the statistically significantly difference.