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. 2021 Mar 19;11:636751. doi: 10.3389/fonc.2021.636751

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Copyright © 2021 Kumamoto, Tasaki, Ohnishi, Shibata, Shimajiri, Harada, Komohara and Nakayama

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Hematoxylin and eosin staining of tumor-stroma ratio (TSR)- low and high. Scale bar = 100 μm. (B) Number of CD8⁺ T cells in TSR-low or high advanced cancer tissues. Correlation between the number of CD8⁺ T cells in TSR-low or high tumor tissues and the CD169/CD68 ratio in lymph node sinus macrophages (LySMs) were tested by Spearman’s correlation test. Scatter plot in TSR-low advanced gastric cancer cases (C) and in TSR-high advanced gastric cancer cases (D) were shown. (E) Kaplan-Meier cancer-specific survival (CSS) curves in patients with TSR-low advanced gastric cancer. (F) Kaplan-Meier CSS curves in patients with TSR-high advanced gastric cancer.