Table 2.
Univariate and multivariate Cox regression analysis of potential prognostic factors for cancer specific survival in patients with total gastric cancer (n = 294) and advanced gastric cancer (n = 159).
| Clinicopathological feature | n | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|---|
| HR | (95%CI) | p | HR | (95%CI) | p | |||
| Total gastric cancer | Age | |||||||
| <70 (y) | 147 | 1.00 | ||||||
| ≥70 (y) | 147 | 1.02 | (0.64 - 1.64) | 0.930 | ||||
| Sex | ||||||||
| Female | 109 | 1.00 | ||||||
| Male | 185 | 1.70 | (1.00 - 2.89) | 0.050 | ||||
| Histology | ||||||||
| Intestinal type | 142 | 1.00 | ||||||
| Diffuse type | 152 | 1.20 | (0.74 - 1.93) | 0.467 | ||||
| Depth of invasion | ||||||||
| m, sm | 135 | 1.00 | ||||||
| mp, ss, se, si | 159 | 17.06 | (6.21 - 46.90) | <0.001 | 3.60 | (1.23 - 10.56) | 0.019 | |
| LN metastasis | ||||||||
| Negative | 175 | 1.00 | ||||||
| Positive | 119 | 10.96 | (5.39 - 19.67) | <0.001 | 3.08 | (1.54 - 6.16) | 0.002 | |
| Distant metastasis | ||||||||
| Negative | 270 | 1.00 | ||||||
| Positive | 24 | 22.95 | (12.90 - 40.84) | <0.001 | 5.70 | (3.02 - 10.76) | <0.001 | |
| Lymphatic invasion | ||||||||
| Negative | 92 | 1.00 | ||||||
| Positive | 202 | 40.88 | (5.14 - 325.30) | <0.001 | 4.87×104 | (0.00 - 5.65×10102) | 0.925 | |
| Vascular invasion | ||||||||
| Negative | 141 | 1.00 | ||||||
| Positive | 153 | 6.52 | (3.33 - 12.77) | <0.001 | 1.01 | (0.49 - 2.09) | 0.984 | |
| Tumor-stroma ratio | ||||||||
| Low | 202 | 1.00 | ||||||
| High | 92 | 6.88 | (4.08 - 11.62) | <0.001 | 2.29 | (1.30 - 4.02) | 0.004 | |
| CD8+cells/mm2 in tumor | ||||||||
| <287 | 147 | 1.00 | ||||||
| ≥287 | 147 | 0.17 | (0.09 - 0.32) | <0.001 | 0.37 | (0.19 - 0.74) | 0.005 | |
| CD169/CD68 ratio in LySMs | ||||||||
| <0.65 | 135 | 1.00 | ||||||
| ≥0.65 | 159 | 0.49 | (0.30 - 0.80) | 0.004 | 0.41 | (0.25 - 0.69) | <0.001 | |
| Advanced gastric cancer | Age | |||||||
| <70 (y) | 80 | 1.00 | ||||||
| ≥70 (y) | 79 | 0.94 | (0.58 - 1.54) | 0.807 | ||||
| Sex | ||||||||
| Female | 54 | 1.00 | ||||||
| Male | 105 | 1.62 | (0.93 - 2.83) | 0.089 | ||||
| Histology | ||||||||
| Intestinal type | 77 | 1.00 | ||||||
| Diffuse type | 82 | 1.41 | (0.86 - 2.32) | 0.175 | ||||
| Depth of invasion | ||||||||
| mp, ss | 121 | 1.00 | ||||||
| se, si | 38 | 7.64 | (4.56 - 12.81) | <0.001 | 2.86 | (1.44 - 5.720) | 0.003 | |
| LN metastasis | ||||||||
| Negative | 57 | 1.00 | ||||||
| Positive | 102 | 4.21 | (2.14 - 8.29) | <0.001 | 3.40 | (1.64 - 7.08) | 0.001 | |
| Distant metastasis | ||||||||
| Negative | 135 | 1.00 | ||||||
| Positive | 24 | 12.61 | (7.00 - 22.70) | <0.001 | 2.91 | (1.32 - 6.43) | 0.008 | |
| Lymphatic invasion | ||||||||
| Negative | 4 | 1.00 | ||||||
| Positive | 155 | 21.10 | (0.04 - 1.15×104) | 0.343 | ||||
| Vascular invasion | ||||||||
| Negative | 32 | 1.00 | ||||||
| Positive | 127 | 1.78 | (0.88 - 3.61) | 0.108 | ||||
| Tumor-stroma ratio | ||||||||
| Low | 84 | 1.00 | ||||||
| High | 75 | 4.84 | (0.12 - 0.42) | <0.001 | 2.54 | (1.37 - 4.68) | 0.003 | |
| CD8+cells/mm2 in tumor | ||||||||
| <287 | 92 | 1.00 | ||||||
| ≥287 | 67 | 0.22 | (0.12 - 0.42) | <0.001 | 0.42 | (0.20 - 0.84) | 0.015 | |
| CD169/CD68 ratio in LySMs | ||||||||
| <0.65 | 69 | 1.00 | ||||||
| ≥0.65 | 90 | 0.36 | (0.22 - 0.60) | <0.001 | 0.38 | (0.22 - 0.66) | <0.001 | |
HR. hazard ratio; CI, confidence interval; m, mucosa; sm, submucosa; mp, muscularis propria; ss, subserosa; se, serosa exposure; si, serosa invasion; LN, lymph node; LySMs, lymph node sinus macrophages.