Table 3.
Univariate and multivariate Cox regression analysis of potential prognostic factors for relapse free survival in patients with total gastric cancer (n = 270) and advanced cancer (n = 135).
| Clinicopathological feature | n | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|---|
| HR | (95%CI) | p | HR | (95%CI) | p | |||
| Total gastric cancer | Age | |||||||
| <70 (y) | 139 | 1.00 | ||||||
| ≥70 (y) | 131 | 0.74 | (0.42 - 1.32) | 0.308 | ||||
| Sex | ||||||||
| Female | 101 | 1.00 | ||||||
| Male | 169 | 1.83 | (0.97 - 3.46) | 0.061 | ||||
| Histology | ||||||||
| Intestinal type | 134 | 1.00 | ||||||
| Diffuse type | 136 | 0.84 | (0.48 - 1.48) | 0.550 | ||||
| Depth of invasion | ||||||||
| m, sm | 135 | 1.00 | ||||||
| mp, ss, se, si | 135 | 13.33 | (4.79 - 37.09) | <0.001 | 3.14 | (1.07 - 9.23) | 0.037 | |
| LN metastasis | ||||||||
| Negative | 172 | 1.00 | ||||||
| Positive | 98 | 9.88 | (4.79 - 20.38) | <0.001 | 3.85 | (1.82 - 8.15) | <0.001 | |
| Distant metastasis | ||||||||
| Negative | 262 | 1.00 | ||||||
| Positive | 8 | 13.90 | (6.05 - 31.93) | <0.001 | 2.34 | (0.99 - 5.57) | 0.054 | |
| Lymphatic invasion | ||||||||
| Negative | 92 | 1.00 | ||||||
| Positive | 178 | 42.94 | (3.87 - 4.77×102) | 0.002 | 2.66×104 | (0.00 - 2.17×1090) | 0.920 | |
| Vascular invasion | ||||||||
| Negative | 138 | 1.00 | ||||||
| Positive | 132 | 6.19 | (2.90 - 13.21) | <0.001 | 1.12 | (0.53 - 2.69) | 0.660 | |
| Tumor-stroma ratio | ||||||||
| Low | 196 | 1.00 | ||||||
| High | 74 | 5.63 | (3.14 - 10.07) | <0.001 | 2.22 | (1.21 - 4.07) | 0.010 | |
| CD8+cells/mm2 in tumor | ||||||||
| <287 | 127 | 1.00 | ||||||
| ≥287 | 143 | 0.17 | (0.08 - 0.17) | <0.001 | 0.21 | (0.10 - 0.45) | <0.001 | |
| CD169+/CD68+cells in RLNs | ||||||||
| <0.65 | 119 | 1.00 | ||||||
| ≥0.65 | 151 | 0.64 | (0.36 - 1.12) | 0.115 | ||||
| Advanced gastric cancer | Age | |||||||
| <70 (y) | 72 | 1.00 | ||||||
| ≥70 (y) | 63 | 0.65 | (0.35 - 1.18) | 0.156 | ||||
| Sex | ||||||||
| Female | 46 | 1.00 | ||||||
| Male | 89 | 1.82 | (0.92 - 3.58) | 0.086 | ||||
| Histology | ||||||||
| Intestinal type | 69 | 1.00 | ||||||
| Diffuse type | 66 | 1.00 | (0.56 - 1.80) | 0.991 | ||||
| Depth of invasion | ||||||||
| mp, ss | 116 | 1.00 | ||||||
| se, si | 19 | 5.53 | (2.93 - 10.42) | <0.001 | 3.64 | (1.64 - 8.11) | 0.002 | |
| LN metastasis | ||||||||
| Negative | 54 | 1.00 | ||||||
| Positive | 81 | 4.03 | (1.87 - 8.67) | <0.001 | 4.97 | (2.19 - 11.27) | <0.001 | |
| Distant metastasis | ||||||||
| Negative | 127 | 1.00 | ||||||
| Positive | 8 | 7.00 | (3.03 - 16.18) | <0.001 | 1.46 | (0.48 - 4.46) | 0.507 | |
| Lymphatic invasion | ||||||||
| Negative | 4 | 1.00 | ||||||
| Positive | 131 | 21.24 | (0.02 - 2.38×104) | 0.394 | ||||
| Vascular invasion | ||||||||
| Negative | 29 | 1.00 | ||||||
| Positive | 106 | 1.62 | (0.72 - 3.63) | 0.240 | ||||
| Tumor-stroma ratio | ||||||||
| Low | 78 | 1.00 | ||||||
| High | 57 | 4.15 | (2.20 - 7.82) | <0.001 | 2.03 | (1.01 - 4.10) | 0.048 | |
| CD8+cells/mm in tumor | ||||||||
| <287 | 72 | 1.00 | ||||||
| ≥287 | 63 | 0.21 | (0.10 - 0.44) | <0.001 | 0.24 | (0.10 - 0.53) | <0.001 | |
| CD169+/CD68+cells in RLNs | ||||||||
| <0.65 | 53 | 1.00 | ||||||
| ≥0.65 | 82 | 0.43 | (0.24 - 0.78) | 0.005 | 0.37 | (0.19 - 0.72) | 0.003 | |
HR. hazard ratio; CI, confidence interval; m, mucosa; sm, submucosa; mp, muscularis propria; ss, subserosa; se, serosa exposure; si, serosa invasion; LN, lymph node; LySMs, lymph node sinus macrophages.