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. 2021 Mar 19;12:654623. doi: 10.3389/fimmu.2021.654623

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Copyright © 2021 Higashioka, Yoshimura, Sakuragi, Ayano, Kimoto, Mitoma, Ono, Arinobu, Kikukawa, Yamada, Horiuchi, Akashi and Niiro

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-21-producing CD8⁺ T cells are enriched in memory PD-1^hi fraction in RAPB and RASF. (A) The upper panels show the representative data regarding the percentage of IL-21-producing CD4⁺ and CD8⁺ T cells in PB and SF of patients with RA and the lower panel summarizes the results (N=18). (B) Correlation of the percentage of IL-21⁺ CD4⁺ T cells with that of IL-21⁺ CD8⁺ T cells in RASF (N=18). (C) The panel summarizes the frequency of synovial IL-21-producing CD8⁺ T cells in RF-positive and -negative patients with RA. (D) The left panels are representative data of the percentage of CD45RA^-PD-1^hi fraction among whole CD8⁺ T cells in OASF (N=3), RAPB (N=12) and RASF (N=18) and right panel summarizes the results. (E) The left panels are representative data of the percentage of IL-21-producing CD8⁺ T cells among CD45RA⁺, CD45RA^-PD-1^-/low, CD45RA^-PD-1^int and CD45RA^-PD-1^hi fractions in RASF and the right panel summarizes the results (N=12). *P < 0.05. **P < 0.01.