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. 2021 Mar 19;12:654623. doi: 10.3389/fimmu.2021.654623

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Copyright © 2021 Higashioka, Yoshimura, Sakuragi, Ayano, Kimoto, Mitoma, Ono, Arinobu, Kikukawa, Yamada, Horiuchi, Akashi and Niiro

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Memory PD-1^hi CD8⁺ T cells share several features with Tph cells in RASF. (A) The panels summarize the percentage of CD28⁺, CD69⁺, ICOS⁺, HLA-DR⁺ and CCR2⁺ among CD45RA⁺, CD45RA^-PD-1^-/low, CD45RA^-PD-1^int and CD45RA^-PD-1^hi fractions in RASF (N=12). (B) The upper panel shows the representative data regarding the percentage of CXCR5^-CD8⁺ T cells in RASF and the lower panel shows representative data on CXCR5⁺CD4⁺ T cells in RAPB. (C) Comparison of levels of MAF, PRDM1, TCF7, and BCL6 mRNA in CD45RA⁺, CD45RA^-PD-1^-/low, CD45RA^-PD-1^int and CD45RA^-PD-1^hi CD8⁺ T cells in RASF (N=6). *P < 0.05; **P < 0.01.