Figure 1.

The targeted therapy principles against herpesvirus: Several metabolic and physiological processes including glycolysis, lipid synthesis, cholesterol metabolism are potentially altered in herpes infected cells (indicated by green boxes). Many cellular/signaling processes are also altered. The infection can be targeted by small-molecule inhibitors (blue) and other drugs. These inhibitors either target cyclin dependent cell cycle, epigenetic factors controlling viral life cycle or DNA damage, etc. Besides, immune cells (purple) and other cells of the tumor microenvironment can be targeted. DNMTi, DNMT inhibitors; HDACi, HDAC inhibitors; HMTi, HMT inhibitor; HDMi, HDM inhibitors; PRC2i, PRC2 inhibitors; EZH2i, EZH2 inhibitors.